| Abstrakt: |
A comparative study of recovery of mitotic cycle in gamma-irradiated rat embryo fibroblast cells (intact, immortalized with oncogene E1A and transformed with two oncogens-E1A and c-Ha-Ras) was made to show eventually no difference in response to 5 Gy irradiation of intact and immortalized cells, and, on the other side, to demonstrate a great difference in response of immortalized and transformed cells. Cells transformed with the two oncogens E1A and c-Ha-Ras appeared to be much more resistant to ionizing radiation than intact cells and cells immortalized with one oncogene E1A. These data allow to suggest protein p53 tumor-suppressor functioning in transformed cells, but not in intact and immortalized cells. |
