| Autor: |
Rossol R; Department of Internal Medicine III, University Hospital, Frankfurt, Germany., Dobmeyer JM, Dobmeyer TS, Klein SA, Rossol S, Wesch D, Hoelzer D, Kabelitz D, Helm EB |
| Jazyk: |
angličtina |
| Zdroj: |
British journal of haematology [Br J Haematol] 1998 Mar; Vol. 100 (4), pp. 728-34. |
| DOI: |
10.1046/j.1365-2141.1998.00630.x |
| Abstrakt: |
Dysregulation of T-cell receptor (TCR) alphabeta bearing lymphocytes and an increase in Vdelta1+ gammadelta T cells are typical features of HIV-1 infection. However, the role of gammadelta T cells remains unclear. Therefore, peripheral blood mononuclear cells (PBMC) of 103 HIV-1-infected patients were investigated with respect to expression of Vdelta1. These results were compared to the Vdelta1 expression of bone marrow mononuclear cells (BMMC). In contrast to healthy controls, Vdelta1+ cells dominated among both PBMC and BMMC in HIV-1-infected patients. Analysis of the coexpression of CD25, CD8, HLA-DR and CD45RO revealed a high prevalence of Vdelta1/CD45RO and Vdelta1/HLA-DR double-positive PBMC only in HIV-1-infected patients but not in healthy donors. Furthermore, analysis of the gammadelta TCR repertoire in patients infected with hepatitis B virus, hepatitis C virus, herpes simplex virus (HSV)-1 and HSV-2 showed that the selective enhancement of Vdelta1+ cells was restricted to HIV infection and not observed in other virus diseases. Our data provide further support for the involvement of gammadelta T cells in immunosuppression and progression of HIV infection. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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