| Abstrakt: |
Two groups of dogs anesthetized with sodium pentobarbital were subjected to compression of 60 psig for 60 min and decompressed at the rate of 10 psi/min without staging. Plasma volume was measured in each group by I131-tagged albumin dilution technique prior to compression, 10 min and 60 min after decompression. One group of animals received no other treatment and the other group received 15 mg/kg of body weight of nicotinic acid by intravenous injection immediately prior to compression and an additional 7.5 mg/kg of body weight of nicotinic acid 30 min after decompression. Both the untreated and the nicotinic acid-treated animals lost significant plasma volume at both the 10- and 60-min postdecompression measurements. Nicotinic acid-treated animals lost significantly less plasma. |
