| Autor: |
Gunatilaka AA; Department of Chemistry, Virginia Polytechnic Institute, Blacksburg, USA., Bolzani Vda S, Dagne E, Hofmann GA, Johnson RK, McCabe FL, Mattern MR, Kingston DG |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of natural products [J Nat Prod] 1998 Feb; Vol. 61 (2), pp. 179-84. |
| DOI: |
10.1021/np9701687 |
| Abstrakt: |
Bioactivity-directed fractionation of the MeCOEt extract of Trichilia emetica (Meliaceae) resulted in the isolation of the limonoids nymania 1 (1), drageana 4 (3), trichilin A (4), rohituka 3 (5), and Tr-B (7) and the novel seco-A protolimonoid 8. Of these, nymania 1 and Tr-B showed selective inhibitory activity toward DNA repair-deficient yeast mutants. The isolation, structure elucidation, 13C NMR spectral assignments, and biological activities of these compounds are reported. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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