Evaluation of a measles vaccine efficacy during a measles outbreak in Mbare, City of Harare Zimbabwe.

Autor:	Mahomva AI; City Health Department, Harare, Zimbabwe., Moyo IM, Mbengeranwa LO
Jazyk:	angličtina
Zdroj:	The Central African journal of medicine [Cent Afr J Med] 1997 Sep; Vol. 43 (9), pp. 254-6.
Abstrakt:	Objective: To determine measles vaccine efficacy. Design: Between October and November 1996, during a measles outbreak in Mbare, a retrospective study through interviews with care givers was performed. Thirty clusters were randomly selected and seven or more, nine to 35 months old children in each cluster were selected. Setting: Mbare suburb, City of Harare Subjects: 294 children aged nine to 35 months. Main Outcome Measures: Cases were classified in a two by two contingency table based on their vaccination status and measles status during the outbreak. Vaccine coverage, attack rates and vaccine efficacy were then calculated. Results: Of the 294 children selected, 83% (95% CI 78.7, 87.3) were vaccinated and 9.5% had measles. The attack rate for the vaccinated was 6.9% while that for the unvaccinated was 22%. Vaccine efficacy was 68%. Conclusion: Vaccine efficacy was found to be low. There is need for serological confirmation of measles cases during outbreaks; for a comprehensive evaluation of the measles vaccination programme in Mbare and for maintenance of high measles vaccine coverage rates to reduce morbidity.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu