Impaired Leydig cell reserve and altered serum androgen binding in the aging male.

Autor: Hallberg MC, Wieland RG, Zorn EM, Furst BH, Wieland JM
Jazyk: angličtina
Zdroj: Fertility and sterility [Fertil Steril] 1976 Jul; Vol. 27 (7), pp. 812-4.
DOI: 10.1016/s0015-0282(16)41958-8
Abstrakt: The hormonal profile of the aging male reveals an associated decrease in free testosterone and 5 alpha-dihydrotestosterone (DHT) levels and increased luteinizing hormone levels. Later events consist of a decrease in total testosterone, stable DHT, and increased follicle-stimulating hormone and estradiol levels. Although most available information supports the concept of impaired Leydig cell reserve, our study suggests some degree of hypothalamic-pituitary dysfunction. The signal for increased androgen binding with age is not clear. There is a great deal of individual variation in the time of onset of these events.
Databáze: MEDLINE