Basal activity of the hypothalamic-pituitary-adrenal axis in patients with the chronic fatigue syndrome (neurasthenia).

Autor: Young AH; University Department of Psychiatry, Warneford Hospital, Oxford, United Kingdom., Sharpe M, Clements A, Dowling B, Hawton KE, Cowen PJ
Jazyk: angličtina
Zdroj: Biological psychiatry [Biol Psychiatry] 1998 Feb 01; Vol. 43 (3), pp. 236-7.
DOI: 10.1016/S0006-3223(97)00404-6
Abstrakt: Background: Impairments in both basal activity and activation of the hypothalamic-pituitary-adrenal axis (HPA) have been reported in chronic fatigue syndrome (CFS; neurasthenia). We sought to replicate these findings and examined basal activity of the HPA in a carefully selected sample of patients with CFS.
Methods: Basal activity of the HPA was assessed using salivary and urinary cortisol collection over a 24-hour period in 22 (12 male; 10 female) patients meeting criteria for CFS and appropriate controls.
Results: Salivary and urinary cortisol measures did not differ between CFS patients and controls.
Conclusions: Basal activity of the HPA was not reduced in CFS patients. Reasons for the failure to replicate previous findings are discussed.
Databáze: MEDLINE
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