[Synthesis of triterpene 2,6-dideoxy-alpha-L-arabino-hexopyranosides from L-rhamnal. Their pharmacological properties].

Autor: Baltina LA, Flekhter OB, Davydova VA, Ismagilova AF, Zarudiĭ FS, Nasyrov KhM, Gromakova LS, Tolstikov GA
Jazyk: ruština
Zdroj: Bioorganicheskaia khimiia [Bioorg Khim] 1997 Oct; Vol. 23 (10), pp. 826-31.
Abstrakt: Triterpene 2,6-dideoxy-alpha-L-arabino-hexopyranosides were synthesized by the glycosylation of oleanane triterpene alcohols with L-rhamnal acetate in the presence of cationite KU-2-8 and lithium bromide. 2,6-Dideoxy-alpha-L-arabino-hexopyranosides of allobetulin and methyl glycyrrhetinate showed pronounced antiulcerous activity; the latter also stimulated reparative skin regeneration in rats and was effective as a hepatoprotectant.
Databáze: MEDLINE