| Autor: |
Everbach EC; Department of Engineering, Swarthmore College, PA 19081-1397, USA., Makin IR, Francis CW, Meltzer RS |
| Jazyk: |
angličtina |
| Zdroj: |
Ultrasound in medicine & biology [Ultrasound Med Biol] 1998 Jan; Vol. 24 (1), pp. 129-36. |
| DOI: |
10.1016/s0301-5629(97)00233-0 |
| Abstrakt: |
A suspension of human platelets in autologous plasma or buffer solution with and without a microbubble echo-contrast agent was exposed in vitro to 730 W/cm2 (ISPPA) ultrasound pulses of duration 40-160 microseconds at 1 MHz and 20-Hz pulse repetition frequency. Inertial cavitation occurring within the samples was monitored during the exposures and a measure of average cavitational activity was calculated for each 5-min exposure. This quantity, with the other acoustic parameters, accounted for up to 75% of the variation in the destruction of platelets as measured by Coulter counter and 83.5% of the release of bound radiolabel using a multiple-interaction statistical model. When the echo-contrast agent was absent, negligible cavitation occurred and the amount of platelet destruction was statistically indistinguishable from sham (no-ultrasound) exposures. Therefore, microbubble echo-contrast agents may interact with ultrasound to cause platelet lysis through the mechanism of inertial cavitation. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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