| Autor: |
Smith KG; Wellcome Trust Immunology Unit, Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, England CB2 2SP., Tarlinton DM, Doody GM, Hibbs ML, Fearon DT |
| Jazyk: |
angličtina |
| Zdroj: |
The Journal of experimental medicine [J Exp Med] 1998 Mar 02; Vol. 187 (5), pp. 807-11. |
| DOI: |
10.1084/jem.187.5.807 |
| Abstrakt: |
Mice in which the Lyn, Cd22, or Shp-1 gene has been disrupted have hyperactive B cells and autoantibodies. We find that in the absence of Lyn, the ability of CD22 to become tyrosine phosphorylated after ligation of mIg, to recruit SHP-1, and to suppress mIg-induced elevation of intracellular [Ca2+] is lost. Therefore, Lyn is required for the SHP-1-mediated B cell suppressive function of CD22, accounting for similarities in the phenotypes of these mice. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
