| Autor: |
Hardarson T; Department of Physiology, University of Iceland, Reykjavik, Iceland. thorasve@rhi.hi.is, Skarphedinsson JO, Sveinsson T |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of applied physiology (Bethesda, Md. : 1985) [J Appl Physiol (1985)] 1998 Feb; Vol. 84 (2), pp. 411-6; discussion 409-10. |
| DOI: |
10.1152/jappl.1998.84.2.411 |
| Abstrakt: |
The purpose of this study was to examine the effects of raising the arterial La- and K+ levels on minute ventilation (VE) in rats. Either La- or KCl solutions were infused in anesthetized spontaneously breathing Wistar rats to raise the respective ion arterial concentration ([La-] and [K+]) gradually to levels similar to those observed during strenuous exercise. VE, blood pressure, and heart rate were recorded continuously, and arterial [La-], [K+], pH, and blood gases were repeatedly measured from blood samples. To prevent changes in pH during the La- infusions, a solution of sodium lactate and lactic acid was used. Raising [La-] to 13.2 +/- 0.6 (SE) mM induced a 47.0 +/- 4.0% increase in VE without any concomitant changes in either pH or PCO2. Raising [K+] to 7.8 +/- 0.11 mM resulted in a 20.3 +/- 5.28% increase in VE without changes in pH. Thus our results show that La- itself, apart from lactic acidosis, may be important in increasing VE during strenuous exercise, and we confirm earlier results regarding the role of arterial [K+] in the control of VE during exercise. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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