| Autor: |
Vasin SL; Center for Blood Compatible Biomaterials, Institute of Transplantology and Artificial Organs, Moscow, Russia., Rosanova IB, Sevastianov VI |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of biomedical materials research [J Biomed Mater Res] 1998 Mar 05; Vol. 39 (3), pp. 491-7. |
| DOI: |
10.1002/(sici)1097-4636(19980305)39:3<491::aid-jbm21>3.0.co;2-c |
| Abstrakt: |
In experiments in vivo using diffusion chambers, the morphology and composition of calcium-containing deposits on natural and artificial biomaterials that had no direct contact with cells were studied using scanning electron microscopy with energy dispersion X-ray microanalysis. It was revealed that the formation of a protein layer containing protein-calcium complexes is the key event in biomaterial calcification. A mechanism of formation of a calcium-containing protein matrix that creates the conditions for supersaturation of the crystal-forming medium over critical value has been proposed. The formation of nuclei of insoluble calcium phosphate starts predominantly deep in an adsorbed protein layer enriched by calcium ions. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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