[Effect of the optimal neuroprotective doses of alpha2-adrenoreceptor agonists on the total cerebral blood flow in the normal conditions and in subsequent ischemia].

Autor: Kulinskiĭ VI; Irkutsk State Medical University, Russia., Medvedeva TN, Usov LA, Ekimov EN
Jazyk: ruština
Zdroj: Eksperimental'naia i klinicheskaia farmakologiia [Eksp Klin Farmakol] 1997 Nov-Dec; Vol. 60 (6), pp. 7-9.
Abstrakt: Optimal neuroprotective doses of clonidine and guanobenz considerably reduce the total cerebral blood flow and reduce or do not change arterial pressure. In occlusion of the carotid arteries the alpha 2-agonists fail to reduce the degree of cerebral ischemia and hypotension. The neuroprotective effect of alpha 2-adrenoceptor-agonists is not a result of cerebral blood flow improvement.
Databáze: MEDLINE