| Autor: |
Beers SA; R.W. Johnson Pharmaceutical Research Institute, Raritan, NJ 08869, USA., Malloy EA, Wu W, Wachter MP, Gunnia U, Cavender D, Harris C, Davis J, Brosius R, Pellegrino-Gensey JL, Siekierka J |
| Jazyk: |
angličtina |
| Zdroj: |
Bioorganic & medicinal chemistry [Bioorg Med Chem] 1997 Dec; Vol. 5 (12), pp. 2203-11. |
| DOI: |
10.1016/s0968-0896(97)00174-0 |
| Abstrakt: |
A series of nitroarylhydroxymethylphosphonic acids was synthesized and evaluated as inhibitors of CD45. It was discovered that both the alpha hydroxy and nitro groups are essential for activity. Potency is enhanced by the addition of a large lipophilic group on the aryl ring adjacent to the phosphonic acid moiety. Kinetics studies have shown that these compounds are competitive inhibitors and thus bind at the active site of this enzyme. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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