Serious hepatitis A: an analysis of patients hospitalized during an urban epidemic in the United States.
| Autor: | Willner IR; University of Tennessee, Memphis 38163, USA., Uhl MD, Howard SC, Williams EQ, Riely CA, Waters B |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Annals of internal medicine [Ann Intern Med] 1998 Jan 15; Vol. 128 (2), pp. 111-4. |
| DOI: | 10.7326/0003-4819-128-2-199801150-00006 |
| Abstrakt: | Background: Memphis and Shelby County, Tennessee, experienced an epidemic of hepatitis A in 1994 and 1995. More than 1700 cases were reported. Objective: To characterize the clinical features of patients hospitalized during a large urban epidemic of hepatitis A. Design: Retrospective chart review. Setting: 15 acute care hospitals in Shelby County, Tennessee. Patients: 256 patients hospitalized with acute hepatitis A. Measurements: Laboratory findings (such as prothrombin time and bilirubin level), complications, and mortality. Results: The median patient age was 26 years. Thirty-nine complications occurred in 35 patients. Twenty patients (8%) had extrahepatic complications, and 5 (2%) died. Patients 40 years of age and older were more likely to have serious complications, including death (P = 0.014). Sixty-seven patients (26%) presented with coagulopathy (prothrombin time > or = 3 seconds prolonged). Fifty-four patients (21%) had a bilirubin level greater than 170 micromol/L (10 mg/dL). Conclusions: During this epidemic, hepatitis A caused serious illness and death. Complications were more frequent in patients 40 years of age and older, but young, healthy persons were also at risk for severe complications. |
| Databáze: | MEDLINE |
| Externí odkaz: |
|