11 beta-substituted 13 beta-ethyl gonane derivatives exhibit reversal of antiprogestational activity.

Autor: Rao PN; Department of Organic Chemistry, Southwest Foundation for Biomedical Research, San Antonio, Texas 78245-0549, USA., Cessac JW, Blye RP, Kim HK
Jazyk: angličtina
Zdroj: Steroids [Steroids] 1998 Jan; Vol. 63 (1), pp. 50-7.
DOI: 10.1016/s0039-128x(97)00119-0
Abstrakt: The syntheses of three 17 alpha-acetoxy-13 beta-ethyl-11 beta-aryl-18,19-dinorpregna-4,9-diene-3,20 diones from levonorgestrel are described. Despite their close structural similarity to the antiprogesterone CDB-2914, one of the compounds exhibits agonistic progestational activity, and the other two compounds are totally inactive.
Databáze: MEDLINE