| Autor: |
Shisler JL; Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 4 Center Drive, MSC 0445, Bethesda, MD 20892-0445, USA., Senkevich TG, Berry MJ, Moss B |
| Jazyk: |
angličtina |
| Zdroj: |
Science (New York, N.Y.) [Science] 1998 Jan 02; Vol. 279 (5347), pp. 102-5. |
| DOI: |
10.1126/science.279.5347.102 |
| Abstrakt: |
Selenium, an essential trace element, is a component of prokaryotic and eukaryotic antioxidant proteins. A candidate selenoprotein homologous to glutathione peroxidase was deduced from the sequence of molluscum contagiosum, a poxvirus that causes persistent skin neoplasms in children and acquired immunodeficiency syndrome (AIDS) patients. Selenium was incorporated into this protein during biosynthesis, and a characteristic stem-loop structure near the end of the messenger RNA was required for alternative selenocysteine decoding of a potential UGA stop codon within the open reading frame. The selenoprotein protected human keratinocytes against cytotoxic effects of ultraviolet irradiation and hydrogen peroxide, providing a mechanism for a virus to defend itself against environmental stress. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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