[Isolation of the fragment D dimer from stabilized fibrin and a study of its antipolymerization action].

Autor: Musialkovskaia AA, Khodorova EL, Pozdniakova TM
Jazyk: ukrajinština
Zdroj: Ukrains'kyi biokhimichnyi zhurnal [Ukr Biokhim Zh] 1976 Mar-Apr; Vol. 48 (2), pp. 139-43.
Abstrakt: The dimer of fragment D is isolated preparatively by CM-cellulose chromatography (in neutral medium) from dialyzed tryptic hydrolyzate of stabilized fibrin. Contrary to the fragment D monomer obtained from fibrinogen under the same conditions, the dimer itself cannot inhibit polymerization of monomeric fibrin. However with the presence of monomer D in the amount sufficient for essential inhibition of the fibrin polymerization the addition of dimer D produces the further delay in polymerization. Under these conditions dimer D is highly effective inhibitor if its amount is not too little, as its small doses are not effective.
Databáze: MEDLINE