| Autor: |
King MD; Royal College of Surgeons Unit of Biophysics, Institute of Child Health, London, UK., Houseman J, Gadian DG, Connelly A |
| Jazyk: |
angličtina |
| Zdroj: |
Magnetic resonance in medicine [Magn Reson Med] 1997 Dec; Vol. 38 (6), pp. 930-7. |
| DOI: |
10.1002/mrm.1910380612 |
| Abstrakt: |
Localized q-space imaging was used to obtain water displacement profiles from mouse brain. These profiles take the form of unidirectional diffusive displacement probability distributions. Two groups of mice were studied, a normal group and a group in which surgery had been performed to produce a unilateral reduction in the supply of blood to the forebrain. q-Space measurements were made both in vivo and postmortem. The displacement profiles were characterized using the summary parameter prob[d < 10], which is the proportion of water molecules that undergo a net diffusive displacement that is less than +/-10 microm, during the diffusion period (50 ms). The range of prob[d < 10] values in the normal group was 0.71 to 0.77 in vivo compared with 0.78 to 0.87 in the impaired hemisphere of the surgically treated group. An increase in prob[d < 10] occurred postmortem to yield values in the range 0.79 to 0.81 and 0.80 to 0.89 in the normal and surgically treated group, respectively. These observations are consistent with the diffusion-weighted image intensity changes that occur after a period of ischemia. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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