| Autor: |
Eibl B; Department of Internal Medicine, University Hospital Innsbruck, Austria., Greiter E, Grünewald K, Gastl G, Weyrer K, Thaler J, Aulitzky W, Herrmann F, Rapp U, Huber C |
| Jazyk: |
angličtina |
| Zdroj: |
Cytokines and molecular therapy [Cytokines Mol Ther] 1995 Mar; Vol. 1 (1), pp. 29-38. |
| Abstrakt: |
This study evaluates (i) constitutive levels of oncogene and p53 transcripts in chronic phase CML patients and (ii) their modulations subsequent to in vivo therapy with rIFN-alpha 2c. Peripheral blood mononuclear cells (pbmc) and bone marrow cells of 26 patients were examined for c-fos, c-myc, p53 and the hybrid bcr/abl mRNA levels. Results indicated that (i) constitutive c-fos transcript levels are significantly higher in patients subsequently responding to IFN-alpha therapy (p < 0.01) and positively correlated with the proportion of lymphocytes (r = 0.6895, p < 0.01) and negatively with the proportion of immature cells (r = -0.568, p < 0.01) contained in the pbmc preparations tested, (ii) constitutive mRNA levels of the hybrid bcr/abl, c-myc and p53 are positively correlated with each other, but failed to relate to disease parameters, and (iii) acute and chronic in vivo exposure to IFN-alpha is accompanied by upregulation of c-fos and downregulation of c-myc mRNA levels in responder patients. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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