| Autor: |
Morishita T; Department of Orthopedic Surgery, Nara Medical University, Japan., Mii Y, Miyauchi Y, Miura S, Honoki K, Aoki M, Kido A, Tamai S, Tsutsumi M, Konishi Y |
| Jazyk: |
angličtina |
| Zdroj: |
Japanese journal of clinical oncology [Jpn J Clin Oncol] 1997 Aug; Vol. 27 (4), pp. 236-9. |
| DOI: |
10.1093/jjco/27.4.236 |
| Abstrakt: |
The efficacy of combination therapy with cis-diammine-dichloroplatinum (II) (CDDP) and o-(chloroacetyl-carbamoyl) fumagillol (AGM-1470) was evaluated experimentally using a transplantable rat osteosarcoma line, previously established in our laboratory, with a high potential for metastasis. Tumor-bearing male Fischer 344 rats were administered CDDP (2.5 mg/kg) together with, or after discontinuation of, AGM-1470 treatment (10 mg/kg/body weight/week). When CDDP was administered three days after discontinuation of AGM-1470 the most pronounced antimetastatic effects were observed, although the antitumor effect was approximately the same. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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