| Autor: |
Gaggi R; Department of Pharmacology, University of Bologna, Italy., Dall' Olio R, Santangelo M, Roncada P |
| Jazyk: |
angličtina |
| Zdroj: |
General pharmacology [Gen Pharmacol] 1997 Sep; Vol. 29 (3), pp. 415-9. |
| DOI: |
10.1016/s0306-3623(96)00484-3 |
| Abstrakt: |
1. The effects of the serotonin (5-HT) precursor, L-5-hydroxytryptophan (L-5-HTP), or the selective 5-HT1A receptor agonist, 8-OHDPAT, on behavior or brain 5-HT metabolism or both were evaluated in rats IP pretreated with nimodipine at doses ranging from 0.31 to 40 mg/kg. 2. Nimodipine, in a wide dose range (0.6-20.0 mg/kg) potentiated the head-twitch response to L-5-HTP. 3. The effects of nimodipine on the 5-HT metabolism of rats treated with L-5-HTP did not comply with the increase in the behavioral response to this 5-HT precursor. 4. Nimodipine antagonized the effects on 5-HT metabolism induced by 8-hydroxy-2-(di-N-propyl-amino)-tetralin through stimulation of 5-HT1A autoreceptors. 5. It was concluded that the effects of nimodipine on brain 5-HT metabolism appeared to be linked to activation of serotonergic neurotransmission likely due to inhibition of the back-regulation mechanism mediated by presynaptic 5-HT1A receptors. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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