The soluble interleukin-2 receptor predicts mortality in older hospitalized men.

Autor: Rosenthal AJ; Medical Service, McGuire VA Medical Center (181), Richmond, VA 23249, USA., McMurtry CT, Sanders KM, Jacobs M, Thompson D, Adler RA
Jazyk: angličtina
Zdroj: Journal of the American Geriatrics Society [J Am Geriatr Soc] 1997 Nov; Vol. 45 (11), pp. 1362-4.
DOI: 10.1111/j.1532-5415.1997.tb02937.x
Abstrakt: Background: There is an inverse relationship between the soluble interleukin-2 receptor (sIL-2R) and serum albumin, cholesterol, transferrin, prealbumin, and hemoglobin. Inasmuch as low serum albumin and cholesterol have been associated with excess mortality, we hypothesized that elevated sIL-2R would predict mortality in older adults.
Objective: To determine if elevated sIL-2R predicts mortality in patients on a geriatric rehabilitation unit.
Design: Prospective cohort.
Setting: University-affiliated VA medical center.
Participants: Seventy-two male patients aged greater than 60 years admitted to a geriatric rehabilitation unit. Patients with severe hepatic or renal disease were excluded.
Measurements: We measured serum albumin, prealbumin, cholesterol, transferrin, hemoglobin, body mass index (BMI), C-reactive protein (CRP), and sIL-2R upon admission. Subjects were followed for 1 year.
Results: Low serum albumin, prealbumin, and hemoglobin and high sIL-2R and CRP predicted 1-year mortality on univariate analysis. When these predictors were included as covariates in a Cox regression model, only sIL-2R was a significant independent predictor of mortality (P = .043). Multiple linear regression with the above covariates revealed that only sIL-2R predicted time to death at (P = .003).
Conclusions: High sIL-2R and CRP and low albumin, prealbumin, and hemoglobin predicted mortality using univariate analysis on a rehabilitation unit. However, with multivariate analysis, sIL-2R was the sole predictor of mortality.
Databáze: MEDLINE
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