Prospective epidemiologic evaluation of laboratory animal allergy among university employees.

Autor: Fuortes LJ; Department of Preventive Medicine and Environmental Health, University of Iowa, Iowa City, USA., Weih L, Pomrehn P, Thorne PS, Jones M, Burmeister L, Merchant JA
Jazyk: angličtina
Zdroj: American journal of industrial medicine [Am J Ind Med] 1997 Dec; Vol. 32 (6), pp. 665-9.
DOI: 10.1002/(sici)1097-0274(199712)32:6<665::aid-ajim13>3.0.co;2-#
Abstrakt: Objectives: Evaluation of incidence and risk factors for development of laboratory animal allergy (LAA) among new hires previously unexposed to lab animals.
Methods: Baseline, 6-month and yearly follow-up, questionnaires, pulmonary functions, and methacholine challenges were collected from 98 never-before occupationally exposed and 90 control laboratory researchers. The two groups were followed between 6 and 36 months.
Results: At baseline, there were no differences in atopy, pulmonary functions, or methacholine reactivity between the two groups. The incidence of work-related asthma was comparable in the two groups, approximately 2.5% at 6 months and 4.5% at 24 months. The rate of decline in FEV1 was statistically significantly greater in the animal-exposed than nonanimal-exposed workers, and animal-exposed smokers' FEV1 declined significantly more rapidly than any other groups'.
Conclusion: Despite the low incidence of laboratory-animal allergy and work-related asthma in this group, this study corroborates previously described interaction between smoking and animal exposure.
Databáze: MEDLINE
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