| Autor: |
Prager MD; Department of Surgery, University of Texas Southwestern Medical Center, Dallas 75235-9031, USA., Quintana RP |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of biomedical materials research [J Biomed Mater Res] 1997 Nov; Vol. 37 (2), pp. 207-11. |
| DOI: |
10.1002/(sici)1097-4636(199711)37:2<207::aid-jbm9>3.0.co;2-v |
| Abstrakt: |
Employing an artificial tear preparation composed of six proteins and six lipids as a deposit model, uptake of the lipids 3H-cholesteryl oleate and 14C-dioleoyl phosphatidylcholine was measured on contact lenses representative of the four FDA hydrogel groups and on select RGP lenses. Cholesteryl oleate uptake after 24 h at 37 degrees C generally was less than 1 microgram/lens although occasionally reaching 1-2 micrograms. DuraSoft 3 lenses (Group IV) accumulated the deposits in greater amounts (p = 0.04) with other lens groups not differing significantly from each other. Ionic DuraSoft 2 and 3 lenses bound more phosphatidylcholine (also < 1 microgram) than other lens groups, possibly reflecting an interaction between the positively charged choline residue and the negative surface of the lens. Lysozyme deposition, measured simultaneously with cholesteryl oleate, bound to a far greater extent to Group IV lenses (e.g., DuraSoft 3, mean surface deposit 279 micrograms) than to other lens types (p < 0.01). Multiple application of the artificial tear solution did not produce a statistically significant increase in cholesteryl oleate accumulation. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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