| Autor: |
Monteclaro FS; Gladstone Institute of Cardiovascular Disease, University of California, San Francisco 94141, USA., Arai H, Charo IF |
| Jazyk: |
angličtina |
| Zdroj: |
Methods in enzymology [Methods Enzymol] 1997; Vol. 288, pp. 70-84. |
| DOI: |
10.1016/s0076-6879(97)88008-1 |
| Abstrakt: |
The construction of chimeric receptors provides a useful starting point for the identification of ligand-binding and G-protein-coupling sites on chemokine receptors. Correlation of the binding and signaling properties of a set of complementary receptor chimeras is a powerful approach for probing structure-function relationships. Further molecular resolution can subsequently be achieved by site-directed mutagenesis and/or alanine scanning. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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