| Autor: |
El Saghir NS; Department of Medicine, American University of Beirut Medical Center, Lebanon., Bizri AR, Shabb NS, Husami TW, Salem Z, Shamseddine AI |
| Jazyk: |
angličtina |
| Zdroj: |
The Journal of infection [J Infect] 1997 Sep; Vol. 35 (2), pp. 179-82. |
| DOI: |
10.1016/s0163-4453(97)91809-0 |
| Abstrakt: |
This is the first report of granulocyte macrophage-colony stimulating factor (GM-CSF) inducing accelerated healing of a sacral pressure ulcer in a bedridden patient with bilateral hemiplegia. GM-CSF was diluted and injected locally around and into the ulcer bed every 2-3 days for 2 weeks, then weekly for 4 weeks until complete healing occurred. A new firm granulation tissue was noted within a few days. The ulcer showed 85% healing within 2 weeks and 100% by 2 months. Healing started from the periphery and from within the ulcer bed at sites of GM-CSF injections. It was slower at areas where there was complete necrosis and detachment of skin from underlying tissue. The ulcer remained closed until the patient's sudden death 9 months later. A biopsy of granulation tissue showed inflammatory cells and reactive fibroblasts. The potential role of GM-CSF and growth factors in pressure ulcer therapy and wound healing are discussed. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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