| Autor: |
Faddis BT; Department of Otolaryngology, Head and Neck Surgery, University of California, School of Medicine, Davis 95616, USA., McGinn MD |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of neurocytology [J Neurocytol] 1997 Sep; Vol. 26 (9), pp. 625-35. |
| DOI: |
10.1023/a:1018593710530 |
| Abstrakt: |
Observations from ultrastructural and immunohistochemical studies suggest that spongiform lesions in the gerbil cochlear nucleus are derived principally from dendrites. Almost one-fifth of the lesion profiles examined ultrastructurally exhibited synaptic contacts with axon terminals. In addition, approximately 80% of lesions are immunopositive for the dendrite-specific microtubule associated protein, MAP2. Ultrastructural studies showed a small percentage (8%) of lesions were derived from myelinated axons, although none were immunohistochemically labelled with antibodies to the tau protein. Staining with the astrocyte-specific markers GFAP, S-100 and vimentin yielded equivocal results, but did not support a major role for astrocytes in lesion formation. The histological profile matches that seen in some other well characterized types of spongiform degeneration. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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