| Autor: |
Goldstone AP; Department of Endocrinology and Metabolic Medicine, Imperial College School of Medicine, Hammersmith Hospital, London, UK., Mercer JG, Gunn I, Moar KM, Edwards CM, Rossi M, Howard JK, Rasheed S, Turton MD, Small C, Heath MM, O'Shea D, Steere J, Meeran K, Ghatei MA, Hoggard N, Bloom SR |
| Jazyk: |
angličtina |
| Zdroj: |
FEBS letters [FEBS Lett] 1997 Sep 29; Vol. 415 (2), pp. 134-8. |
| DOI: |
10.1016/s0014-5793(97)01103-4 |
| Abstrakt: |
The adipose tissue hormone, leptin, and the neuropeptide glucagon-like peptide-1 (7-36) amide (GLP-1) both reduce food intake and body weight in rodents. Using dual in situ hybridization, long isoform leptin receptor (OB-Rb) was localized to GLP-1 neurons originating in the nucleus of the solitary tract. ICV injection of the specific GLP-1 receptor antagonist, exendin(9-39), at the onset of dark phase, did not affect feeding in saline pre-treated controls, but blocked the reduction in food intake and body weight of leptin pre-treated rats. These findings suggest that GLP-1 neurons are a potential target for leptin in its control of feeding. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
Plný text