| Autor: |
Morlevat F; Centre de Pathologie, IRMB, Dijon., Roignot P, Lizard-Nacol S, Brunet-Lecomte P, Lizard G |
| Jazyk: |
francouzština |
| Zdroj: |
Archives d'anatomie et de cytologie pathologiques [Arch Anat Cytol Pathol] 1997; Vol. 45 (1), pp. 13-21. |
| Abstrakt: |
The analysis of p53 expression has been performed on 58 cases of colonic carcinomas. p53 expression was revealed by immunohistochemistry with the monoclonal antibody DO.7, and its quantification was performed by image analysis on deparaffinized tissue sections treated by microwaves. p53 expression evaluated by images analysis has been compared to visual estimation performed under light microscopy, and an excellent correlation was found between the two methods. No statistical significant relationships were found between the proportion of tumours expressing p53, sex, age (< 70 or > 70 years), histology (well, intermediate or poorly differentiated) and DNA index (< 1.3 or > 1.3) whereas the proportion of tumors expressing p53 was significantly higher in case of metastatic behaviour as well as in the C stage of Dukes classification. p53 expression was also significantly more important in colonic carcinomas with DNA index higher than 1.3 and in case of metastatic behaviour. According to these data, the metastatic behaviour is correlated both with the proportion of tumors expressing p53 and with the level of p53 expression. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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