| Autor: |
Matheson GK; Neurobiology Laboratory, Indiana University, School of Medicine, Evansville 44712, USA. Matheson@indyvax.iupui.edu, Knowles A, Gage D, Michel C, Guthrie D, Bauer C, Blackbourne J, Weinzapfel D |
| Jazyk: |
angličtina |
| Zdroj: |
Pharmacology [Pharmacology] 1997 Aug; Vol. 55 (2), pp. 59-65. |
| DOI: |
10.1159/000139513 |
| Abstrakt: |
The effects of tandospirone, enciprazine, gepirone, buspirone (5-HT1A agents) and carvotroline (5-HT2) on hypothalamic-pituitary-adrenocortical activity (HPA) activity were studied. These drugs increased the plasma corticosterone levels in a dose-dependent manner. Their ED50 values were 3.8, 31.8, 3.1, 3.4 and 7.0 mg/kg, respectively. Drug effects peaked between 30 min and 1 h, and plasma corticosterone levels returned to control levels after 2 h. When the drugs were given in conjunction with a rotatory stress, gepirone and enciprazine increased and carvotroline decreased plasma corticosterone levels. Dexamethasone (0.1 mg/kg) pretreatment reduced drug-activated HPA axis activity. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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