| Autor: |
Men Y; Institute of Biochemistry, University of Lausanne, Epalinges, Switzerland., Tamber H, Audran R, Gander B, Corradin G |
| Jazyk: |
angličtina |
| Zdroj: |
Vaccine [Vaccine] 1997 Aug-Sep; Vol. 15 (12-13), pp. 1405-12. |
| DOI: |
10.1016/s0264-410x(97)00047-9 |
| Abstrakt: |
We have previously reported that biodegradable polymer microspheres (MS) are capable of eliciting strong and long-lasting antibody and T cell proliferative responses for either natural protein antigens or synthetic peptides. In this study, we investigated the possibility of inducing antigen-specific cytotoxic T lymphocyte (CTL) responses in vivo with a short synthetic peptide from the circumsporozoite (CS) protein of Plasmodium berghei (Pb) 252-260 by using different MS formulations. We show that injection of mice with a short CTL epitope microencapsulated in MS or adsorbed on empty MS enhanced a specific CTL response comparable to that obtained with the incomplete Freund's adjuvant (IFA) formulation, indicating that MS are a potent antigen delivery system/immunostimulant for CTL response. These results might be of practical interest for MS preparation and development of subunit vaccines. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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