| Autor: |
Ramharack R; Department of Vascular and Cardiac Diseases, Parke-Davis Pharmaceutical Research, Ann Arbor, Michigan 48105, USA. ramharr@aa.wl.com, Spahr MA, Sekerke CS |
| Jazyk: |
angličtina |
| Zdroj: |
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 1997 Sep 08; Vol. 238 (1), pp. 48-52. |
| DOI: |
10.1006/bbrc.1997.7240 |
| Abstrakt: |
Elevated plasma lipoprotein(a) [Lp(a)] independently contributes to a variety of vascular diseases; consequentially, factors that modulate its levels are of interest. Since Lp(a) is produced by a disulfide linkage between apolipoprotein(a) [apo(a)] and apolipoproteinB-100 (apoB-100) of low density lipoprotein (LDL) on the hepatocyte surface, modulation of either particle may be useful in lowering Lp(a). Using primary cynomolgus monkey hepatocyte cultures that endogenously express apo(a) and apoB-100, we showed that all-trans (retinol, retinal, retinoic acid) and 9-cis (retinal, retinoic acid) retinoids lower Lp(a) accumulation in the cell media, with the 9-cis derivatives being > 10-fold more potent than the all-trans stereoisomers. Lp(a) Towering was related to decreases in apo(a) and its cognate transcript, but not to apoB-100. These results demonstrate that retinoids lower Lp(a) levels by decreasing apo(a) through its cognate mRNA. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
Full Text from ScienceDirect