| Autor: |
Ellis MC; Mercator Genetics, Inc., 4040 Campbell Ave., Menlo Park, CA 94025, USA., Hetisimer AH, Ruddy DA, Hansen SL, Kronmal GS, McClelland E, Quintana L, Drayna DT, Aldrich MS, Mignot E |
| Jazyk: |
angličtina |
| Zdroj: |
Immunogenetics [Immunogenetics] 1997; Vol. 46 (5), pp. 410-7. |
| DOI: |
10.1007/s002510050295 |
| Abstrakt: |
A systematic haplotype and sequencing analysis of the HLA-DR and -DQ region in patients with narcolepsy was performed. Five new (CA)n microsatellite markers were generated and positioned on the physical map across the HLA-DQB1-DQA1-DRB1 interval. Haplotypes for these new markers and the three HLA loci were established using somatic cell hybrids generated from patients. A four-marker haplotype surrounding the DQB1(*)0602 gene was found in all narcolepsy patients, and was identical to haplotypes observed on random chromosomes harboring the DQB1(*)0602 allele. Eighty-six kilobases of contiguous genomic sequence across the region did not reveal new genes, and analysis of this sequence for single nucleotide polymorphisms did not reveal sequence variation among DQB1(*)0602 chromosomes. These results are consistent with other studies, suggesting that the HLA-DQ genes themselves are among the predisposing factors in narcolepsy. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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