| Autor: |
Wong SW; Division of Pathobiology and Immunology, Oregon Regional Primate Research Center, Beaverton 97006, USA., Swanson RM, Bergquam EP |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of medical primatology [J Med Primatol] 1997 Feb-Apr; Vol. 26 (1-2), pp. 59-62. |
| DOI: |
10.1111/j.1600-0684.1997.tb00320.x |
| Abstrakt: |
A cDNA fragment specific for the rhesus macaque gibbon ape leukemia virus (GaLV) receptor (Glvr-1) was isolated by polymerase chain reaction (PCR) amplification and oligonucleotide primers specific for human Glvr-1 and a cDNA library derived from rhesus macaque brain. Sequence analysis of the fragment revealed the polypeptide domain necessary for infection by GaLV. This fragment was utilized to elucidate expression levels of Glvr-1 RNA in rhesus macaque tissues. By Northern blot analysis, Glvr-1 RNA is most abundantly expressed in the thymus and bone marrow, with detectable levels also in the brain and testes of juvenile male macaques. In the developing 70-days gestation fetus, Glvr-1 expression was observed predominately in the liver and spleen. Although additional studies are required, these studies support the notion that cell types involved in hematopoiesis express Glvr-1. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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