| Autor: |
Oshitani H; Virus Research Centre, National Sendai Hospital, Japan., Suzuki H, Mpabalwani M, Mizuta K, Kasolo FC, Luo NP, Numazaki Y |
| Jazyk: |
angličtina |
| Zdroj: |
Tropical medicine & international health : TM & IH [Trop Med Int Health] 1997 Jul; Vol. 2 (7), pp. 612-6. |
| DOI: |
10.1046/j.1365-3156.1997.d01-346.x |
| Abstrakt: |
Laboratory diagnosis of measles infection is rarely performed in developing countries and tends to depend on clinical symptoms alone. We evaluated detection of immunoglobulin M (IgM) antibodies for confirmation of acute measles infection in Zambia. In 149 hospitalized children with clinical diagnosis of measles, IgM antibodies were detected in 88.6% (132/149). The IgM-positive rate increased with time after onset of skin rash and all samples were positive after 4 days. In addition to IgM antibody test, virus isolations from throat swabs using B95a cells were also performed. These were positive in only 20.9% (14/67), and both IgM and virus isolation in combination increased the positive rate to 92.5% (62/67). Vaccinated children had higher neutralizing (Nt) antibody responses and, among IgM-negative patients, all 4 vaccinated children had high Nt antibodies while all 10 unvaccinated children had negative or low Nt results. The IgM antibody test was proved to be a sensitive method for laboratory confirmation of measles virus infection in developing countries. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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