| Autor: |
Orisakwe OE; College of Health Sciences, Nnamdi Azikiwe University Nnewi Campus, Anambra State, Nigeria., Dioka CE, Okpogba AN, Orish CN, Ofoefule SI |
| Jazyk: |
angličtina |
| Zdroj: |
The Tokai journal of experimental and clinical medicine [Tokai J Exp Clin Med] 1996 Feb; Vol. 21 (1), pp. 51-4. |
| Abstrakt: |
The effect of activated charcoal (AC) on rifampicin excretion was investigated in six healthy volunteers. On three occasions, at weekly intervals, each subject received a 600 mg rifampicin with 350 ml of water; b+c one and two weeks later, 600 mg of rifampicin plus 7.5 and 15 g AC, respectively, in 350 ml of water as a charcoal slurry. Urinary levels of rifampicin were measured form 1-36 hr after ingestion. Treatment with AC led to 1.2 per cent urinary recovery of rifampicin; decreased excretion rate; and a much lower plateau indicative of reduced absorption. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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