| Autor: |
Okonya JF; Department of Chemistry and Biochemistry, University of Notre Dame, IN 46556, USA., Kolasa T, Miller MJ |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of peptide science : an official publication of the European Peptide Society [J Pept Sci] 1996 May-Jun; Vol. 2 (3), pp. 157-64. |
| DOI: |
10.1002/psc.61 |
| Abstrakt: |
Pseudobactin is a structurally complex and physiologically important siderophore (microbial iron chelator] from Pseudomonas putida-fluorescens. Various fragments of the unusual peptide component of pseudobactin listed below were prepared by solution-phase peptide synthesis. L-Lys.D-threo-beta-OH Asp.L-Ala.D-allo-Thr.L-Ala L-Lys.D-threo-beta OH Asp.L-Ala.D-allo-Thr D-threo-beta-OH Asp.L-Ala.D-allo-Thr.L-Ala.D-N-OH-cycloOrn D-threo-beta-OH-Asp.L-Ala.D-allo-Thr.L-Ala L-Ala.D-allo-Thr.L-Ala.D-N-OH-cycloOrn A class of related peptides named pseudomycins have shown promising antifungal activity. To examine if these peptide fragments above would elicit similar activity, the fragments were tested and found to have no antifungal activity in limited bioassays. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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