Implantation of colon cancer at trocar sites is increased by low pressure pneumoperitoneum.

Autor: Wu JS; Department of Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA., Brasfield EB, Guo LW, Ruiz M, Connett JM, Philpott GW, Jones DB, Fleshman JW
Jazyk: angličtina
Zdroj: Surgery [Surgery] 1997 Jul; Vol. 122 (1), pp. 1-7.
DOI: 10.1016/s0039-6060(97)90256-7
Abstrakt: Background: The purpose of this study was to determine the effect of pneumoperitoneum on the implantation of tumor at trocar sites.
Methods: GW-39 human colon cancer cell suspension (0.5 ml of 2.5% v/v) was injected into the peritoneal cavity of golden Syrian hamsters through a 1 cm midline incision. Four 5 mm trocars were inserted through the anterior abdominal wall, and the midline incision was then closed. The animals were randomized to receive pneumoperitoneum (n = 62) or no pneumoperitoneum (n = 60) for 10 minutes. Tumor implantations at trocar sites and midline wound incisions were documented grossly and histologically 8 weeks later.
Results: Tumor was identified in 86% (49 of 57) of control animals and 95% (52 of 55) of the experimental group (p = 0.20). Implants increased with pneumoperitoneum at the midline incision from 44% to 71% (p < 0.01) and at trocar sites from 41% to 64% (p < 0.00001).
Conclusions: Pneumoperitoneum significantly increased tumor implantation at trocar sites and midline incisions.
Databáze: MEDLINE
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