| Autor: |
Sansoni P; Istituto di Clinica Medica Generale e Terapia Medica, University of Parma, Italy., Fagnoni F, Vescovini R, Mazzola M, Brianti V, Bologna G, Nigro E, Lavagetto G, Cossarizza A, Monti D, Franceschi C, Passeri M |
| Jazyk: |
angličtina |
| Zdroj: |
Mechanisms of ageing and development [Mech Ageing Dev] 1997 Jun; Vol. 96 (1-3), pp. 127-36. |
| DOI: |
10.1016/s0047-6374(97)01887-3 |
| Abstrakt: |
It is generally assumed that T cell proliferation is impaired in aged individuals. We report data on the proliferative capability of peripheral blood mononuclear cells (PBMC) and T lymphocytes from 40 healthy people of different ages, (19-107 years), including 14 centenarians, to defined mitogenic stimuli. We observed no age-related proliferative impairment both in PBMC and in purified T cells stimulated by anti-CD3 mAb or phorbol myristate acetate (PMA). Furthermore, T cells stimulated by anti-CD3 mAb or PMA and costimulated by CD28 mAb did not proliferate differently among young, middle aged subjects and centenarians. Thus, short term T cell proliferation is not affected even at extreme age when well defined stimuli are used on cells deriving from carefully selected healthy subjects. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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