| Autor: |
Vianello F; Institute of Medical Semeiotics, University of Padua Medical School, Padova, Italy., Radossi P, Tison T, Dazzi F, Tagariello G, Davoli PG, Girolami A |
| Jazyk: |
angličtina |
| Zdroj: |
British journal of haematology [Br J Haematol] 1997 Jun; Vol. 97 (4), pp. 807-9. |
| DOI: |
10.1046/j.1365-2141.1997.1082922.x |
| Abstrakt: |
The aim of our study was to investigate whether haemophilia A patients with inversion of intron 22 are at high risk for non-inhibitory anti-FVIII antibodies development detected by ELISA. It is known that patients with severe forms of haemophilia A are more likely to develop anti-FVIII antibodies. The incidence of inhibitory anti-FVIII antibodies in patients with factor VIII gene inversion has been extensively evaluated, but if this defect has to be considered a predisposing factor is still debatable. Non-inhibitory anti-FVIII antibodies are attracting interest, due to the potential influence on FVIII half-life. Our data show that FVIII gene inversion was a major predisposing factor for anti-FVIII antibodies development. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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