| Autor: |
Otten SL; School of Pharmacy, University of Wisconsin, Madison 53706, USA., Gallo MA, Madduri K, Liu X, Hutchinson CR |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of bacteriology [J Bacteriol] 1997 Jul; Vol. 179 (13), pp. 4446-50. |
| DOI: |
10.1128/jb.179.13.4446-4450.1997 |
| Abstrakt: |
Characterization of the dnmZ, dnmU, and dnmV genes from the daunorubicin-producer Streptomyces peucetius by DNA sequence analysis indicated that these genes encode a protein of unknown function plus a putative thymidine diphospho-4-keto-6-deoxyglucose-3(5)-epimerase and thymidine diphospho-4-ketodeoxyhexulose reductase, respectively. Inactivation of each of the three genes by gene disruption and replacement in the wild-type strain demonstrated that all of them are required for daunosamine biosynthesis. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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