| Autor: |
Boĭko SS, Zherdev VP, Dvorianinov AA, Gudasheva TA, Ostrovskaia RU, Voronina TA, Rozantsev GG, Seredenin SB |
| Jazyk: |
ruština |
| Zdroj: |
Eksperimental'naia i klinicheskaia farmakologiia [Eksp Klin Farmakol] 1997 Mar-Apr; Vol. 60 (2), pp. 53-5. |
| Abstrakt: |
The pharmacokinetics of a new nootropic dipeptide analog of piracetam-N-phenylacetyl-L-prolylglycine (GWS-111) and its main metabolites were studied in rats by means of high performance liquid chromatography and gas-liquid chromatography. The compound under study showed a greater resistance to an enzymatic effect than natural neuropeptides. In addition to an unchanged compound three of its metabolites were found in the blood plasma of the rats. One of them, cyclo-Pro-Gly was an active metabolite of GWS-111. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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