| Autor: |
Gerlt JA; Department of Biochemistry, University of Illinois, 600 South Mathews Avenue, Urbana, IL 61801, USA. j-gerlt@uiuc.edu, Kreevoy MM, Cleland W, Frey PA |
| Jazyk: |
angličtina |
| Zdroj: |
Chemistry & biology [Chem Biol] 1997 Apr; Vol. 4 (4), pp. 259-67. |
| DOI: |
10.1016/s1074-5521(97)90069-7 |
| Abstrakt: |
We have proposed previously that short, strong hydrogen bonds exist in enzyme active sites and that they are important in explaining enzymic rate enhancements. Here, we defend this proposal and provide evidence for likely changes of hydrogen bond strengths during enzymic catalysis. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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