| Autor: |
Masycheva VI, Danilenko ED, Morozova EN, Fedosova LK, Sizova LIu, Gamaleĭ SG, Lebedev LR, Pustoshilova NM |
| Jazyk: |
ruština |
| Zdroj: |
Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] [Antibiot Khimioter] 1997; Vol. 42 (4), pp. 24-7. |
| Abstrakt: |
Toxic properties of recombinant human tumor necrosis factor (TNF-beta) were studied on noninbred albino mice. In the maximum tolerable doses the preparation induced a decrease in the body weight and temperature of the animals as well as development of glyco- and leukopenic reactions and damage of the internal organ structures. The preparation effects were observed early after the exposure and were mainly reversible. The most TNF-beta sensitive organs were the liver, lungs, adrenal gland, thymus and spleen. The major link in the pathological process development under the effect of the TNF-beta toxic doses was likely increased intravascular blood coagulability evident from a marked procoagulant activity of the preparation. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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