| Autor: |
Gahring LC; Geriatric Research, Education, and Clinical Center, Veterans Affairs Medical Center, Salt Lake City, Utah, 84148, USA. lgahring@genetics.utah.edu, White HS, Skradski SL, Carlson NG, Rogers SW |
| Jazyk: |
angličtina |
| Zdroj: |
Neurobiology of disease [Neurobiol Dis] 1997; Vol. 3 (4), pp. 263-9. |
| DOI: |
10.1006/nbdi.1996.0123 |
| Abstrakt: |
We examined the expression of the sleep-inducing cytokine interleukin-1alpha (IL-1alpha) in the brains of audiogenic seizure-susceptible mice subsequent to the induction of sound-induced seizure. Animal models of epilepsy often require lesioning or trauma that may nonspecifically alter IL-1alpha expression. To avoid this, we employed the Frings mouse strain; a model of auditory-evoked reflex epilepsy. Frings mice were exposed to a high-intensity sound stimulus to induce a tonic extension seizure, and the expression of IL-1alpha transcripts in different brain regions was measured thereafter. Compared to control animals, IL-1alpha transcripts were elevated 6 to 8 h postseizure in the hypothalamus, but not hippocampus, by a dexamethasone-sensitive pathway. Similar results were obtained from the genetically distinct DBA/2J audiogenic seizure-susceptible mouse strain. These findings demonstrate that the expression of IL-1alpha is altered following generalized seizure activity, induced by noninvasive sensory stimulation, in a brain-region-specific manner. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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