| Autor: |
Chen YL; Medicinal Chemistry Department, Pfizer Inc., Groton, Connecticut 06340, USA. yuhpyng_l_chen@groton.pfizer.com., Mansbach RS, Winter SM, Brooks E, Collins J, Corman ML, Dunaiskis AR, Faraci WS, Gallaschun RJ, Schmidt A, Schulz DW |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of medicinal chemistry [J Med Chem] 1997 May 23; Vol. 40 (11), pp. 1749-54. |
| DOI: |
10.1021/jm960861b |
| Abstrakt: |
The syntheses of a centrally active nonpeptide CRF1 receptor antagonist 2, butylethyl[2,5-dimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo [2,3-d]pyrimidin-4-yl]amine (CP-154,526), and its analogs 11-14 and [3H]-2 are reported. The in vitro CRF1 receptor binding affinity in the series 2, the pharmacokinetic properties of 2 in rats, and the anxiolytic-like effects of orally administered 2 are presented. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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