Fine needle aspiration cytology of pleomorphic adenoma. An analysis of 212 cases.
| Autor: | Viguer JM; Department of Pathology, Hospital La Paz, Madrid, Spain., Vicandi B, Jiménez-Heffernan JA, López-Ferrer P, Limeres MA |
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| Jazyk: | angličtina |
| Zdroj: | Acta cytologica [Acta Cytol] 1997 May-Jun; Vol. 41 (3), pp. 786-94. |
| DOI: | 10.1159/000332705 |
| Abstrakt: | Objective: To assess the value of fine needle aspiration cytology (FNAC) in the diagnosis of pleomorphic adenoma and to determine the cytologic variations responsible for diagnostic errors. Study Design: We retrospectively studied 212 cases cytologically diagnosed as pleomorphic adenoma. In 184 a histologic diagnosis was available. Fourteen cases of histologically proven pleomorphic adenomas with a previously erroneous cytologic diagnosis were also reviewed. This study was based on those cases with a histologic diagnosis. Results: The sensitivity and specificity of the cytologic diagnosis of pleomorphic adenoma in our series were 92.6% and 98.4%, respectively. In relation to malignancy, the series showed six false negative and three false positive diagnoses. In those cases correctly diagnosed on aspiration (175), a typical cytologic appearance, with no diagnostic difficulties, was observed in 118 cases (67.4%); the remainder showed cytologic variations. Cellular atypia (20.6%), cystic transformation (7%) and the presence of a cylindromatous pattern (5%) resembling adenoid cystic carcinoma were the most common cytologic variations observed and responsible for the majority of the errors. Conclusion: The cytologic variations in FNAC of pleomorphic adenoma must be considered in order to avoid important errors in the preoperative management of and surgical approach to salivary gland lesions. |
| Databáze: | MEDLINE |
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