4-Aminopyridine improves pulmonary function in quadriplegic humans with longstanding spinal cord injury.

Autor: Segal JL; Medicine Service, Department of Veterans Affairs Medical Center, Long Beach, CA 90822, USA., Brunnemann SR
Jazyk: angličtina
Zdroj: Pharmacotherapy [Pharmacotherapy] 1997 May-Jun; Vol. 17 (3), pp. 415-23.
Abstrakt: Study Objective: To test the hypothesis that 4-aminopyridine (4-AP) might cause clinically evident improvement in pulmonary function in humans with chronic spinal cord injury (chronic SCI).
Design: Balanced, open-label study with subjects consecutively enrolled.
Setting: Spinal Cord Injury Service, university-affiliated tertiary level care Department of Veterans Affairs Medical Center.
Patients: Seventeen healthy men and women suffering from traumatic SCI (11 quadriplegic, 6 paraplegic patients) for more than 1 year.
Interventions: Each subject was given a single dose of 4-AP 10 mg orally in an immediate-release formulation.
Measurements and Main Results: Significant increases in mean values of forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), maximal inspiratory pressure (MIP), and maximal expiratory pressure (MEP) that persisted for at least 12 hours were demonstrated in quadriplegic patients beginning 6 hours after 4-AP administration. Tests of pulmonary function that demonstrated statistically significant increases at any time were also numerically, if not statistically, increased at 24 hours compared with pretreatment values obtained in 4-AP-naive subjects.
Conclusions: The administration of a single dose of an immediate-release formulation of 4-AP to humans with longstanding, traumatic quadriplegia is associated with sustained, clinically meaningful, and statistically significant improvements in pulmonary function. We suggest that the administration of 4-AP may have a salutary effect in patients suffering from SCI and appears to be associated with potentially clinically significant reductions in the pathophysiologic pulmonary sequelae of SCI.
Databáze: MEDLINE
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