Combination intravenous ceftazidime and aminoglycosides in the treatment of pseudomonal scleritis.
| Autor: | Helm CJ; UCLA Ocular Inflammatory Disease Center, Jules Stein Eye Institute, UCLA 90095-7003, USA., Holland GN, Webster RG Jr, Maloney RK, Mondino BJ |
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| Jazyk: | angličtina |
| Zdroj: | Ophthalmology [Ophthalmology] 1997 May; Vol. 104 (5), pp. 838-43. |
| DOI: | 10.1016/s0161-6420(97)30225-5 |
| Abstrakt: | Background: Pseudomonal scleritis is a serious and potentially blinding infection that usually is resistant to medical management. Methods: Results for three patients with pseudomonal scleritis who were treated with both topical anti-infectives and a combination of intravenous ceftazidime and aminoglycoside are presented in this case series. Results: All three patients had a rapid response to the addition of combination intravenous drug therapy to topical therapy; eradication of the infection and healing of the ocular surface occurred within 8 weeks. Only one patient, in whom cystoid macular edema developed, lost useful vision as a result of the infection. Conclusions: Combination therapy with intravenous ceftazidime and aminoglycoside may be more effective than single-intravenous agents when used in addition to topical antibiotics and may obviate the need for adjunctive surgical procedures, such ascryotherapy, surgical extirpation, or conjunctival recession. |
| Databáze: | MEDLINE |
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